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Counsyl Inherited Cancer Screen gene list

The following genes are currently available for hereditary cancer screening.

View available panels

GeneAssociated syndromeBreastOvarianEndometrialColorectalPancreaticGastricProstateThyroidMelanomaNeuroendocrine
Comprehensive Panel genes

APC

Familial adenomatous polyposis

X

X

X

X

ATM

ATM-associated hereditary cancer

X

X

BMPR1A

Juvenile polyposis

X

X

BRCA1

BRCA-related breast and ovarian cancer syndrome

X

X

X

X

BRCA2

BRCA-related breast and ovarian cancer syndrome

X

X

X

X

X

BRIP1

BRIP1-associated hereditary cancer

X

CDH1

Hereditary diffuse gastric cancer

X

X

X

CDK4

Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome

X

CDKN2A

Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome

X

X

CHEK2

CHEK2-associated hereditary cancer

X

X

EPCAM

Lynch syndrome

X

X

X

X

X

GREM1

Hereditary mixed polyposis syndrome (HMPS)

X

MLH1

Lynch syndrome

X

X

X

X

X

MSH2

Lynch syndrome

X

X

X

X

X

MSH6

Lynch syndrome

X

X

X

X

X

MUTYH

MUTYH-associated polyposis

X

PALB2

PALB2-associated hereditary cancer

X

X

PMS2

Lynch syndrome

X

X

X

X

X

POLD1

Polymerase proofreading associated polyposis (PPAP) syndrome

X

X

POLE

Polymerase proofreading associated polyposis (PPAP) syndrome

X

PTEN

PTEN hamartoma tumor syndrome

X

X

X

X

RAD51C

RAD51C-associated hereditary cancer

X

RAD51D

RAD51D-associated hereditary cancer

X

RET

Multiple endocrine neoplasia, type 2

X

X

SMAD4

Juvenile polyposis

X

X

STK11

Peutz-Jeghers

X

X

X

X

X

X

TP53

Li-Fraumeni syndrome

X

X

X

X

X

X

X

X

X

VHL

Von Hippel-Lindau

X

Additional Expanded Panel genes

BARD1

BARD1-associated hereditary cancer

X

X

MEN1

Multiple endocrine neoplasia, type 1

X

MRE11A

MRE11A-associated hereditary cancer

X

X

NBN

NBN-associated hereditary cancer

X

RAD50

RAD50-associated hereditary cancer

X

X

SDHA

Hereditary paraganglioma-pheochromocytoma

X

SDHB

Hereditary paraganglioma-pheochromocytoma

X

SDHC

Hereditary paraganglioma-pheochromocytoma

X

Table not representative of all possible cancer risks.

Inherited Cancer Screen Panels

Select one of the panel options below, or create a custom panel with any other combination of genes.

Comprehensive Panel

Includes 28 genes with clear cancer risks and patient management guidelines

  • APC
  • ATM
  • BMPR1A
  • BRCA1
  • BRCA2
  • BRIP1
  • CDH1
  • CDK4
  • CDKN2A
  • CHEK2
  • EPCAM
  • GREM1
  • MLH1
  • MSH2
  • MSH6
  • MUTYH
  • PALB2
  • PMS2
  • POLD1
  • POLE
  • PTEN
  • RAD51C
  • RAD51D
  • RET
  • SMAD4
  • STK11
  • TP53
  • VHL

Expanded Panel

Includes all genes from the Comprehensive Panel plus these 8 additional genes

  • BARD1
  • MEN1
  • MRE11A
  • NBN
  • RAD50
  • SDHA
  • SDHB
  • SDHC

BRCA Panel

Full sequencing of BRCA1 and BRCA2, including large deletions and duplications

  • BRCA1
  • BRCA2

Lynch Syndrome Panel

Includes genes from the Comprehensive Panel associated with Lynch Syndrome

  • EPCAM
  • MLH1
  • MSH2
  • MSH6
  • PMS2

Breast Panel

Includes genes from the Comprehensive Panel associated with breast cancer

  • ATM
  • BRCA1
  • BRCA2
  • CDH1
  • CHEK2
  • PALB2
  • PTEN
  • STK11
  • TP53

Melanoma Panel

Includes genes from the Comprehensive Panel associated with melanoma

  • BRCA2
  • CDK4
  • CDKN2A

Pancreatic Panel

Includes genes from the Comprehensive Panel associated with pancreatic cancers

  • APC
  • ATM
  • BRCA1
  • BRCA2
  • CDKN2A
  • EPCAM
  • MLH1
  • MSH2
  • MSH6
  • PALB2
  • PMS2
  • STK11
  • TP53

Gynecological Panel

Includes genes from the Comprehensive Panel associated with ovarian, endometrial, and other gynecological cancers

  • BRCA1
  • BRCA2
  • BRIP1
  • EPCAM
  • MLH1
  • MSH2
  • MSH6
  • PMS2
  • POLD1
  • PTEN
  • RAD51C
  • RAD51D
  • STK11
  • TP53

Gastrointestinal Panel

Includes genes from the Comprehensive Panel associated with gastric, colorectal, and other gastrointestinal cancers

  • APC
  • BMPR1A
  • CDH1
  • CHEK2
  • EPCAM
  • GREM1
  • MLH1
  • MSH2
  • MSH6
  • MUTYH
  • PMS2
  • POLD1
  • POLE
  • PTEN
  • SMAD4
  • STK11
  • TP53

Neuroendocrine Panel

Includes genes associated with neuroendocrine tumors

  • MEN1
  • RET
  • SDHA
  • SDHB
  • SDHC
  • VHL